Arriving in September 2025 POLA Wrinkle Shot Medical Serum N Quasi-drug, Serum Sample 0.2g x 10 packets Retail Price: 20g ¥14,850 Description: The first wrinkle-improving cosmetic in Japan, Wrinkle Shot, has been renewed. POLA's unique quasi-drug active ingredient "Niel One," discovered from approximately 5400 types of materials. "Niel One," a quasi-drug active ingredient that inhibits neutrophil elastase. Niel One is a component consisting of four amino acid derivatives that inhibits the function of neutrophil elastase and improves wrinkles. It balances the production and breakdown of dermal components, improving wrinkles.