Arriving December 2025 POLA Wrinkle Shot Medical Serum N Quasi-drug cosmetic serum Sample 0.2g x 20 packets Retail price: 20g ¥14,850 《Product Description》 The first wrinkle-improving cosmetic in Japan, Wrinkle Shot, has been renewed. POLA's original quasi-drug active ingredient "Niel One," discovered from approximately 5,400 types of materials. "Niel One," a quasi-drug active ingredient that inhibits neutrophil elastase. Niel One is a component consisting of four amino acid derivatives that inhibits the function of neutrophil elastase and improves wrinkles. It improves wrinkles by balancing the production and breakdown of dermal components.