ROSALIEVE REDNESS REDUCING COMPLEX 30ml Jan Marini Rosalieve Face Lotion Jan Marini Expiration Date: 2026 [Focusing on the chain reaction of redness, for a skin impression with a sense of transparency] An innovative, patented solution that approaches the inflammatory spiral, which causes chronic redness, from three directions. Rosacea is thought to be caused by various stimuli such as Demodex mites, acne bacteria, external temperature, allergies, and ultraviolet rays, which activate immune sensors (TLR2). This activation causes an excessive release of antimicrobial peptides such as cathelicidin, leading to vascular abnormalities. Rosalieve contains the peptide Tetrapeptide-14. Tetrapeptide-14 downregulates the inflammatory cytokine IL-6, suppressing abnormal inflammation and reducing redness. Furthermore, Tetrapeptide-14 has a regulatory effect on the antimicrobial peptide LL37, which is produced by the activation of cathelicidin. LL37 is known to be involved in abnormal blood vessel formation. In other words, Tetrapeptide-14 can be expected to suppress abnormal blood vessels. Rosalieve also contains many anti-inflammatory substances such as azelaic acid, allantoin, and ranunculus extract. Contents: 30ml Purchased at a beauty clinic