I've only read it once. I checked for things like dog-ears, but there aren't any. I handled it with care, but please refrain from purchasing if you are overly concerned about minor details. Thank you. An encyclopedia packed with amazing knowledge about the brain. - Title: The Amazing Brain Encyclopedia - Publisher: Poplar Publishing - Price: 1,000 yen (excluding tax) - ISBN: 9784591167564 - Series Total: 200,000 copies Thank you for looking.