Arriving in October 2025 POLA Wrinkle Shot Medical Serum N Quasi-drug serum Sample 0.2g x 20 packets Retail price: 20g ¥14,850 《Product Description》 The first Japanese medicinal wrinkle improvement cosmetic, Wrinkle Shot, has been renewed and is now available. POLA's unique quasi-drug active ingredient "Niel One," discovered from approximately 5,400 types of materials. "Niel One," a quasi-drug active ingredient that inhibits neutrophil elastase. Niel One is a component consisting of four amino acid derivatives that inhibits the action of neutrophil elastase and improves wrinkles. It balances the production and breakdown of dermal components, improving wrinkles.